Effects of L-lysine aescinat on intracranial pressure in patients with severe traumatic brain injury

Methods Twenty patients with TBI and Glasgow coma scale below 9 enrolled in the study. Mean age was 39.3 ± 13.6 years, male/female 18/2. All patients were operated: 6 patients underwent craniotomy and intracranial hematoma removing; 11 decompressive craniotomy and intracranial hematoma removing. In 3 patients only ICP-sensor was implanted. ICP-monitoring was used in all patients. Ten patients were randomized to L-lysine aescinat treatment (daily dose of 20 ml for 7 days after surgery) (study group), 10 to standard therapy (control group). We perfomed a comparative analysis of the mean ICP and the incidence of ICH within 7 days after surgery in the study and control groups.